We have described the first organocatalytic stereoselective formylation of ketones accomplished by the use of N-methybenzothiazolylium iodide. The benzothiazolium salt, generally used as a masked formyl group or as precursor of carbenes,[31] is quite electrophilic and react with enamines formed in situ. Both moderate yield and high stereoselectivity were obtained with different ketones.
Capdevila, M.G., Emer, E., Gualandi, A., Petruzziello, D., Grilli, S., Cozzi, P.G. (2012). Organocatalytic Stereoselective α-Formylation of Ketones. CHEMCATCHEM, 4(7), 968-971 [10.1002/cctc.201200122].
Organocatalytic Stereoselective α-Formylation of Ketones
GUALANDI, ANDREA;GRILLI, STEFANO;COZZI, PIER GIORGIO
2012
Abstract
We have described the first organocatalytic stereoselective formylation of ketones accomplished by the use of N-methybenzothiazolylium iodide. The benzothiazolium salt, generally used as a masked formyl group or as precursor of carbenes,[31] is quite electrophilic and react with enamines formed in situ. Both moderate yield and high stereoselectivity were obtained with different ketones.File in questo prodotto:
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