Childhood asymmetric labium majus enlargement (CALME) is a rare and distinctive soft tissue lesion which specifically arises in prepubertal years; CALME, whose nature is still debated, is a slow-growing lesion that in some cases may spontaneously regress; however, because of its unilaterality and lack of definable borders CALME can mimic more aggressive soft tissue vulvar tumors. Therefore CALME is commonly treated with surgery. Herein we describe a mass of the right labium majus presenting in a 12-years-old female in the absence of any significant endocrine unbalance and associated pathol- ogy; the clinical, histopathological and ultrastructural findings were consistent with the diagnoses of CALME. We discuss the differential diagnosis and review the complete literature on this subject. On the bases of clinical, histopathological and ultrastructural features it is believed that CALME should be considered a hyperplastic / reactive lesion derived from stromal fibroblasts.
N.C.F. Salfi, M.Nanni, E.Barbieri, L.Foroni, M.Lima, S.Venturoli (2007). Ingrossamento asimmetrico del grande labbro della vulva:descrizione di un caso e revisione della letteratura. LA RIVISTA ITALIANA DI OSTETRICIA E GINECOLOGIA., 13, 643-646.
Ingrossamento asimmetrico del grande labbro della vulva:descrizione di un caso e revisione della letteratura
LIMA, MARIO;
2007
Abstract
Childhood asymmetric labium majus enlargement (CALME) is a rare and distinctive soft tissue lesion which specifically arises in prepubertal years; CALME, whose nature is still debated, is a slow-growing lesion that in some cases may spontaneously regress; however, because of its unilaterality and lack of definable borders CALME can mimic more aggressive soft tissue vulvar tumors. Therefore CALME is commonly treated with surgery. Herein we describe a mass of the right labium majus presenting in a 12-years-old female in the absence of any significant endocrine unbalance and associated pathol- ogy; the clinical, histopathological and ultrastructural findings were consistent with the diagnoses of CALME. We discuss the differential diagnosis and review the complete literature on this subject. On the bases of clinical, histopathological and ultrastructural features it is believed that CALME should be considered a hyperplastic / reactive lesion derived from stromal fibroblasts.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.