Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognizes a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (cHL), reflecting the differences in clinical presentation and behavior, morphology, phenotype, and molecular features. cHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted. The borders between cHL and anaplastic large-cell lymphoma have become sharper, whereas those between LP-HL and T-cell-rich B-cell lymphoma remain ill defined. Treatments adjusted to the pathobiological characteristics of the tumor in at-risk patients have been proposed and are on the way to being applied

Pathobiology of hodgkin lymphoma.

PICCALUGA, PIER PAOLO;AGOSTINELLI, CLAUDIO;GAZZOLA, ANNA;BACCI, FRANCESCO;SABATTINI, ELENA;SISTA, MARIA TERESA;MANNU, CLAUDIA;SAPIENZA, MARIA ROSARIA;ROSSI, MAURA;LAGINESTRA, MARIA ANTONELLA;SAGRAMOSO SACCHETTI, CARLO ALBERTO;RIGHI, SIMONA;PILERI, STEFANO
2011

Abstract

Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognizes a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (cHL), reflecting the differences in clinical presentation and behavior, morphology, phenotype, and molecular features. cHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted. The borders between cHL and anaplastic large-cell lymphoma have become sharper, whereas those between LP-HL and T-cell-rich B-cell lymphoma remain ill defined. Treatments adjusted to the pathobiological characteristics of the tumor in at-risk patients have been proposed and are on the way to being applied
Piccaluga P.P.; Agostinelli C.; Gazzola A.; Tripodo C.; Bacci F.; Sabattini E.; Sista M.T.; Mannu C.; Sapienza M.R.; Rossi M.; Laginestra M.A.; Sagramoso-Sacchetti C.A.; Righi S.; Pileri S.A.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/120952
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