We faced the basic question on chronological versus biological age at tissue level in the context of organ transplant. By means of a comprehensive approach we analysed nuclear and mitochondrial DNA, mRNAs, microRNAs, proteins, including proteasome and immunoproteasome, obtained from liver biopsies of donors with different age (13-90 years) to identify biomarkers of biological age. Telomere length and specific miRNAs appear to be important biomarkers of liver aging. This research looks for the improvement of the graft management getting insights into donor- recipient age- mismatch effects.
M. Capri, F. Olivieri, D. Remondini, C. Lanzarini, R. Lazzarini, E. Bellavista, et al. (2011). ORGAN-SPECIFIC BIOMARKERS OF HUMAN AGING: THE CASE OF LIVER. BOLOGNA : Bononia University Press.
ORGAN-SPECIFIC BIOMARKERS OF HUMAN AGING: THE CASE OF LIVER
CAPRI, MIRIAM;REMONDINI, DANIEL;LANZARINI, CATIA;BELLAVISTA, ELENA;MARTUCCI, MORENA;SANTORO, AURELIA;BIONDI, FIAMMETTA;VASURI, FRANCESCO;D'ERRICO, ANTONIETTA;DAZZI, ALESSANDRO;PELLEGRINI, SARA;CASTELLANI, GASTONE;CESCON, MATTEO;GRAZI, GIAN LUCA;FRANCESCHI, CLAUDIO
2011
Abstract
We faced the basic question on chronological versus biological age at tissue level in the context of organ transplant. By means of a comprehensive approach we analysed nuclear and mitochondrial DNA, mRNAs, microRNAs, proteins, including proteasome and immunoproteasome, obtained from liver biopsies of donors with different age (13-90 years) to identify biomarkers of biological age. Telomere length and specific miRNAs appear to be important biomarkers of liver aging. This research looks for the improvement of the graft management getting insights into donor- recipient age- mismatch effects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
