The first synthesis of m-hydroxymexiletine (MHM) has been accomplished. MHM displayed hNav1.5 sodium channel blocking activity, and tests indicate it to be ∼2-fold more potent than the parent mexiletine and to have more favorable toxicological properties than mexiletine. Thus, MHM and possible related prodrugs might be studied as agents for the treatment of arrhythmias, neuropathic pain, and myotonias in substitution of mexiletine (metabolite switch), which has turned out to be tainted with common toxicity.
Synthesis and Toxicopharmacological Evaluation of meta-Hydroxymexiletine, the First Metabolite of Mexiletine more Potent than the Parent Compound on Voltage-gated Sodium Channels / Catalano A; Desaphy J-F; Lentini G; Carocci A; Di Mola A; Bruno C; Carbonara R; De Palma A; Budriesi R; Ghelardini C; Perrone MG; Colabufo NA; Conte Camerino D; Franchini C. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - STAMPA. - 55:(2012), pp. 1418-1422. [10.1021/jm201197z]
Synthesis and Toxicopharmacological Evaluation of meta-Hydroxymexiletine, the First Metabolite of Mexiletine more Potent than the Parent Compound on Voltage-gated Sodium Channels.
BUDRIESI, ROBERTA;
2012
Abstract
The first synthesis of m-hydroxymexiletine (MHM) has been accomplished. MHM displayed hNav1.5 sodium channel blocking activity, and tests indicate it to be ∼2-fold more potent than the parent mexiletine and to have more favorable toxicological properties than mexiletine. Thus, MHM and possible related prodrugs might be studied as agents for the treatment of arrhythmias, neuropathic pain, and myotonias in substitution of mexiletine (metabolite switch), which has turned out to be tainted with common toxicity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
