Intensity-modulated radiotherapy (IMRT) enables a better conformality to the target while sparing the surrounding normal tissues and potentially allows to increase the dose to the target, if this is precisely and accurately determined. The goal is to determine inter-fraction setup errors and prostate motion in IMRT guided by daily kilovoltage computed tomography (kVCBCT), eventually to reduce the costly daily IMRT procedure. A simulated Adaptive Radiation Therapy (ART) protocol using the average of the first 5 kVCBCTs was tested by non-parametric bootstrapping procedure. Shifts were < 1 mm in left-right (LR) and in supero-inferior (SI) direction. In antero-posterior (AP) direction systematic prostate motion (2.7 ± 0.7 mm) gave the major contribution to the variability of results; the averages of the absolute total shifts were significantly larger in anterior (6.3 ± 0.2 mm) than in posterior (3.9 ± 0.2 mm) direction. The ART protocol would reduce margins in LR, SI and anterior but not in posterior direction.
M. Palombarini, S. Mengoli, P. Fantazzini, C. Cadioli, C. Degli Esposti, G. P. Frezza (2012). Analysis of inter-fraction setup errors and organ motion by daily kilovoltage cone beam computed tomography in intensity modulated radiotherapy of prostate cancer. RADIATION ONCOLOGY, 7, 1-8 [10.1186/1748-717X-7-56].
Analysis of inter-fraction setup errors and organ motion by daily kilovoltage cone beam computed tomography in intensity modulated radiotherapy of prostate cancer
MENGOLI, STEFANO;FANTAZZINI, PAOLA;
2012
Abstract
Intensity-modulated radiotherapy (IMRT) enables a better conformality to the target while sparing the surrounding normal tissues and potentially allows to increase the dose to the target, if this is precisely and accurately determined. The goal is to determine inter-fraction setup errors and prostate motion in IMRT guided by daily kilovoltage computed tomography (kVCBCT), eventually to reduce the costly daily IMRT procedure. A simulated Adaptive Radiation Therapy (ART) protocol using the average of the first 5 kVCBCTs was tested by non-parametric bootstrapping procedure. Shifts were < 1 mm in left-right (LR) and in supero-inferior (SI) direction. In antero-posterior (AP) direction systematic prostate motion (2.7 ± 0.7 mm) gave the major contribution to the variability of results; the averages of the absolute total shifts were significantly larger in anterior (6.3 ± 0.2 mm) than in posterior (3.9 ± 0.2 mm) direction. The ART protocol would reduce margins in LR, SI and anterior but not in posterior direction.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
