Several studies support the use of probiotics for the treatment of minor gastrointestinal problems in infants. Positive effects on newborn colics have been evidenced after administration of Lactobacillus strains, whereas no studies have been reported regarding the use of bifidobacteria for this purpose. This work was therefore aimed at the characterization of Bifidobacterium strains capable of inhibiting the growth of pathogens typical of the infant gastrointestinal tract and of coliforms isolated from colic newborns. Among the 46 Bifidobacterium strains considered, 16 showed high antimicrobial activity against potential pathogens; these strains were further characterized from a taxonomic point of view, for the presence and transferability of antibiotic resistances, for citotoxic effects and adhesion to nontumorigenic gut epithelium cell lines. Moreover, their ability to stimulate gut health by increasing the metabolic activity and the immune response of epithelial cells was also studied. The examination of all these features allowed to identify three Bifidobacterium breve strains and a Bifidobacterium longum subsp. longum strain as potential probiotics for the treatments of enteric disorders in newborns such as infantile colics. A validation clinical trial involving the selected strains is being planned.

Aloisio I., Santini C., Biavati B., Dinelli G., Cencic A., Chingwaru W., et al. (2012). Characterization of Bifidobacterium spp. strains for the treatment of enteric disorders in newborns. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 96, 1561-1576 [10.1007/s00253-012-4138-5].

Characterization of Bifidobacterium spp. strains for the treatment of enteric disorders in newborns.

ALOISIO, IRENE;SANTINI, CECILIA;BIAVATI, BRUNO;DINELLI, GIOVANNI;DI GIOIA, DIANA
2012

Abstract

Several studies support the use of probiotics for the treatment of minor gastrointestinal problems in infants. Positive effects on newborn colics have been evidenced after administration of Lactobacillus strains, whereas no studies have been reported regarding the use of bifidobacteria for this purpose. This work was therefore aimed at the characterization of Bifidobacterium strains capable of inhibiting the growth of pathogens typical of the infant gastrointestinal tract and of coliforms isolated from colic newborns. Among the 46 Bifidobacterium strains considered, 16 showed high antimicrobial activity against potential pathogens; these strains were further characterized from a taxonomic point of view, for the presence and transferability of antibiotic resistances, for citotoxic effects and adhesion to nontumorigenic gut epithelium cell lines. Moreover, their ability to stimulate gut health by increasing the metabolic activity and the immune response of epithelial cells was also studied. The examination of all these features allowed to identify three Bifidobacterium breve strains and a Bifidobacterium longum subsp. longum strain as potential probiotics for the treatments of enteric disorders in newborns such as infantile colics. A validation clinical trial involving the selected strains is being planned.
2012
Aloisio I., Santini C., Biavati B., Dinelli G., Cencic A., Chingwaru W., et al. (2012). Characterization of Bifidobacterium spp. strains for the treatment of enteric disorders in newborns. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 96, 1561-1576 [10.1007/s00253-012-4138-5].
Aloisio I.; Santini C.; Biavati B.; Dinelli G.; Cencic A.; Chingwaru W.; Mogna L.; Di Gioia D.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/118890
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 22
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 51
social impact