In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.
Serretti A., Chiesa A., Crisafulli C., Massat I., Linotte S., Calati R., et al. (2012). Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression. NEUROPSYCHOBIOLOGY, 65, 70-75 [10.1159/000329553].
Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression.
SERRETTI, ALESSANDRO;CALATI, RAFFAELLA;DE RONCHI, DIANA;
2012
Abstract
In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
