Several small organic molecule catalysts are reminiscent of natural enzymes in their mode of action and substrate interaction/activation. This striking similarity has been a great source of inspiration for the development of new organocatalytic asymmetric processes. A few representative examples, mostly dealing with catalysts interacting through multiple hydrogen-bonds (synthetic oxyanion holes), are highlighted in this perspective.
L. Bernardi, M. Fochi, M. Comes Franchini, A. Ricci (2012). Bioinspired organocatalytic asymmetric reactions. ORGANIC & BIOMOLECULAR CHEMISTRY, 10, 2911-2922 [10.1039/c2ob07037e].
Bioinspired organocatalytic asymmetric reactions
BERNARDI, LUCA;FOCHI, MARIAFRANCESCA;COMES FRANCHINI, MAURO;RICCI, ALFREDO MARCO
2012
Abstract
Several small organic molecule catalysts are reminiscent of natural enzymes in their mode of action and substrate interaction/activation. This striking similarity has been a great source of inspiration for the development of new organocatalytic asymmetric processes. A few representative examples, mostly dealing with catalysts interacting through multiple hydrogen-bonds (synthetic oxyanion holes), are highlighted in this perspective.File in questo prodotto:
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