Several small organic molecule catalysts are reminiscent of natural enzymes in their mode of action and substrate interaction/activation. This striking similarity has been a great source of inspiration for the development of new organocatalytic asymmetric processes. A few representative examples, mostly dealing with catalysts interacting through multiple hydrogen-bonds (synthetic oxyanion holes), are highlighted in this perspective.
Bioinspired organocatalytic asymmetric reactions / L. Bernardi; M. Fochi; M. Comes Franchini; A. Ricci. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - STAMPA. - 10:(2012), pp. 2911-2922. [10.1039/c2ob07037e]
Bioinspired organocatalytic asymmetric reactions
BERNARDI, LUCA;FOCHI, MARIAFRANCESCA;COMES FRANCHINI, MAURO;RICCI, ALFREDO MARCO
2012
Abstract
Several small organic molecule catalysts are reminiscent of natural enzymes in their mode of action and substrate interaction/activation. This striking similarity has been a great source of inspiration for the development of new organocatalytic asymmetric processes. A few representative examples, mostly dealing with catalysts interacting through multiple hydrogen-bonds (synthetic oxyanion holes), are highlighted in this perspective.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
