During the last decade a tremendous technologic progress based on genome-wide profiling of genetic aberrations, structural DNA alterations, and sequence variations has allowed a better understanding of the molecular basis of pediatric and adult B/T-acute lymphoblastic leukemia (ALL), contributing to a better recognition of the biological heterogeneity of ALL and to a more precise definition of risk factors. Importantly, these advances identified novel potential targets for therapeutic intervention. This review will be focused on the cytogenetic/molecular advances in pediatric and adult ALL based on recently published articles.
Iacobucci I, Papayannidis C, Lonetti A, Ferrari A, Baccarani M, Martinelli G. (2012). Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 7(2), 133-143 [10.1007/s11899-012-0122-5].
Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments.
IACOBUCCI, ILARIA;PAPAYANNIDIS, CRISTINA;LONETTI, ANNALISA;FERRARI, ANNA;BACCARANI, MICHELE;MARTINELLI, GIOVANNI
2012
Abstract
During the last decade a tremendous technologic progress based on genome-wide profiling of genetic aberrations, structural DNA alterations, and sequence variations has allowed a better understanding of the molecular basis of pediatric and adult B/T-acute lymphoblastic leukemia (ALL), contributing to a better recognition of the biological heterogeneity of ALL and to a more precise definition of risk factors. Importantly, these advances identified novel potential targets for therapeutic intervention. This review will be focused on the cytogenetic/molecular advances in pediatric and adult ALL based on recently published articles.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
