The prevalence of gastroesophageal reflux disease (GERD) and related disorders has been increasing worldwide, particularly in Western populations where a parallel rise in obesity prevalence has been reported. As weight gain often overlaps with the GERD-related symptoms, several recent studies investigated the significance of this correlation, mainly using meta-analyses. Here, we discuss the large amount of evidence linking obesity and GERD-related symptoms, providing potential mechanisms for their co-occurrence. Particular attention is given also to the association between obesity, Barrett's esophagus and esophageal adenocarcinoma development.
Eusebi LH, Fuccio L, Bazzoli F (2012). The Role of Obesity in Gastroesophageal Reflux Disease and Barrett's Esophagus. DIGESTIVE DISEASES, 30, 154-157 [10.1159/000336668.].
The Role of Obesity in Gastroesophageal Reflux Disease and Barrett's Esophagus.
EUSEBI, LEONARDO HENRY UMBERTO;FUCCIO, LORENZO;BAZZOLI, FRANCO
2012
Abstract
The prevalence of gastroesophageal reflux disease (GERD) and related disorders has been increasing worldwide, particularly in Western populations where a parallel rise in obesity prevalence has been reported. As weight gain often overlaps with the GERD-related symptoms, several recent studies investigated the significance of this correlation, mainly using meta-analyses. Here, we discuss the large amount of evidence linking obesity and GERD-related symptoms, providing potential mechanisms for their co-occurrence. Particular attention is given also to the association between obesity, Barrett's esophagus and esophageal adenocarcinoma development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
