Genetic transformation of fruit tree species is a promising tool to improve one specific trait of a cultivar without changing its overall characteristics. However, Genetically Modified (GM) foods are not accepted worldwide; in Europe there is persistent suspicion of GM crops, and supermarkets often display the label “GMfree”. One of the main health safety concerns about GM foods relates to allergenicity. Fruits of the Rosaceae family, mainly apples, are reported as the plant food most frequently involved in allergic reactions. To date four major families of apple allergens are reported, i.e., Mal d 1, Mal d 2, Mal d 3 and Mal d 4, each including several genes called also isoforms. Mal d 1, -2 and -3 are also known as pathogenesis-related (PR) proteins, while Mal d 4 is classified as profilin with a putative actin-binding role. Within the European ISAFRUIT project the potential risk of increased allergenicity in GM plants was investigated through the study of allergen genes expression in HcrVf2 transgenic scab resistant lines, in comparison with the isogenic cultivar and a classically bred cultivar with the same resistance gene.
R. Paris, G. Pagliarani, S. Tartarini, S. Sansavini, C. Gessler, E. van de Weg (2012). Allergen Expression in Control and Transgenic Apple Plants. LEUVEN : ISHS.
Allergen Expression in Control and Transgenic Apple Plants
PARIS, ROBERTA;PAGLIARANI, GIULIA;TARTARINI, STEFANO;SANSAVINI, SILVIERO;
2012
Abstract
Genetic transformation of fruit tree species is a promising tool to improve one specific trait of a cultivar without changing its overall characteristics. However, Genetically Modified (GM) foods are not accepted worldwide; in Europe there is persistent suspicion of GM crops, and supermarkets often display the label “GMfree”. One of the main health safety concerns about GM foods relates to allergenicity. Fruits of the Rosaceae family, mainly apples, are reported as the plant food most frequently involved in allergic reactions. To date four major families of apple allergens are reported, i.e., Mal d 1, Mal d 2, Mal d 3 and Mal d 4, each including several genes called also isoforms. Mal d 1, -2 and -3 are also known as pathogenesis-related (PR) proteins, while Mal d 4 is classified as profilin with a putative actin-binding role. Within the European ISAFRUIT project the potential risk of increased allergenicity in GM plants was investigated through the study of allergen genes expression in HcrVf2 transgenic scab resistant lines, in comparison with the isogenic cultivar and a classically bred cultivar with the same resistance gene.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
