A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50= 45 M) has been found on glioblastoma cell lines.
E. Locatelli, F. Broggi, J. Ponti, P. Marmorato, F. Franchini, S. Lena, et al. (2012). Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-based micelles for the treatment of Glioblastoma. ADVANCED HEALTHCARE MATERIALS, 1, 342-347 [10.1002/adhm.201100047].
Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-based micelles for the treatment of Glioblastoma.
LOCATELLI, ERICA;COMES FRANCHINI, MAURO
2012
Abstract
A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50= 45 M) has been found on glioblastoma cell lines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
