We have described the first catalytic stereoselective addition of aldehydes to internal functionalized propargylic alcohols, promoted by a combination of an organocatalyst and indium triflate. The reaction is tolerant of a range of functional groups and was performed in the presence of water.
R. Sinisi, M. Vita, A. Gualandi, E. Emer, P. Cozzi (2011). S(N)1-Type Reactions in the Presence of Water: Indium(III)-Promoted Highly Enantioselective Organocatalytic Propargylation of Aldehydes. CHEMISTRY-A EUROPEAN JOURNAL, 17, 7404-7408 [10.1002/chem.201100729].
S(N)1-Type Reactions in the Presence of Water: Indium(III)-Promoted Highly Enantioselective Organocatalytic Propargylation of Aldehydes
GUALANDI, ANDREA;COZZI, PIER GIORGIO
2011
Abstract
We have described the first catalytic stereoselective addition of aldehydes to internal functionalized propargylic alcohols, promoted by a combination of an organocatalyst and indium triflate. The reaction is tolerant of a range of functional groups and was performed in the presence of water.File in questo prodotto:
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