We have reported an effective and very simple method to effect the enantioselective direct alkylation of aldehydes with unfunctionalized alcohols. This methodology opens several opportunities for realizing cascade, consecutive, and multicomponent organocatalytic reactions that include benzylic alcohols in their synthetic design
Highly Enantioselective α Alkylation of Aldehydes with 1,3-Benzodithiolylium Tetrafluoroborate: A Formal Organocatalytic α Alkylation of Aldehydes by the Carbenium Ion / A. Gualandi; E. Emer; M. Guteras Capdevila; P. Cozzi. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - STAMPA. - 50:(2011), pp. 7842-7846. [10.1002/anie.201102562]
Highly Enantioselective α Alkylation of Aldehydes with 1,3-Benzodithiolylium Tetrafluoroborate: A Formal Organocatalytic α Alkylation of Aldehydes by the Carbenium Ion
GUALANDI, ANDREA;COZZI, PIER GIORGIO
2011
Abstract
We have reported an effective and very simple method to effect the enantioselective direct alkylation of aldehydes with unfunctionalized alcohols. This methodology opens several opportunities for realizing cascade, consecutive, and multicomponent organocatalytic reactions that include benzylic alcohols in their synthetic designI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
