We have reported an effective and very simple method to effect the enantioselective direct alkylation of aldehydes with unfunctionalized alcohols. This methodology opens several opportunities for realizing cascade, consecutive, and multicomponent organocatalytic reactions that include benzylic alcohols in their synthetic design
A. Gualandi, E. Emer, M. Guteras Capdevila, P. Cozzi (2011). Highly Enantioselective α Alkylation of Aldehydes with 1,3-Benzodithiolylium Tetrafluoroborate: A Formal Organocatalytic α Alkylation of Aldehydes by the Carbenium Ion. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 50, 7842-7846 [10.1002/anie.201102562].
Highly Enantioselective α Alkylation of Aldehydes with 1,3-Benzodithiolylium Tetrafluoroborate: A Formal Organocatalytic α Alkylation of Aldehydes by the Carbenium Ion
GUALANDI, ANDREA;COZZI, PIER GIORGIO
2011
Abstract
We have reported an effective and very simple method to effect the enantioselective direct alkylation of aldehydes with unfunctionalized alcohols. This methodology opens several opportunities for realizing cascade, consecutive, and multicomponent organocatalytic reactions that include benzylic alcohols in their synthetic designI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
