Objective This study aimed to see whether clinical healing after amalgam removal corresponds to histological healing, i.e. a complete disappearance of any histological sign of lichenoid lesion. Study design The study evaluated 64 patients with lichenoid lesions and at least one amalgam filling. Results After amalgam removal, complete clinical healing was obtained in 14 patients (22%) and was significantly related to lesion topography (chi square 4.7; p<.05) and positive patch test (chi square 6.3; p<.01). Complete histological healing was only obtained in 7 cases (50% of clinically healed patients), and was significantly related to the combination of positive patch test and strict contact with amalgams (Fisher’s exact test p<.01). Conclusions Contact with amalgams and positive patch testing are good but not absolute indicators of the beneficial effect of amalgam replacement. In addition, complete clinical healing does not necessarily mean a disappearance of the histological characteristics of OLL/OLP lesions.

Clinical and histologic healing of lichenoid oral lesions following amalgam removal: a prospective study.

MONTEBUGNOLI, LUCIO;GISSI, DAVIDE BARTOLOMEO;CERVELLATI, FABIO
2012

Abstract

Objective This study aimed to see whether clinical healing after amalgam removal corresponds to histological healing, i.e. a complete disappearance of any histological sign of lichenoid lesion. Study design The study evaluated 64 patients with lichenoid lesions and at least one amalgam filling. Results After amalgam removal, complete clinical healing was obtained in 14 patients (22%) and was significantly related to lesion topography (chi square 4.7; p<.05) and positive patch test (chi square 6.3; p<.01). Complete histological healing was only obtained in 7 cases (50% of clinically healed patients), and was significantly related to the combination of positive patch test and strict contact with amalgams (Fisher’s exact test p<.01). Conclusions Contact with amalgams and positive patch testing are good but not absolute indicators of the beneficial effect of amalgam replacement. In addition, complete clinical healing does not necessarily mean a disappearance of the histological characteristics of OLL/OLP lesions.
ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS
Montebugnoli L.; Venturi M.; Gissi DB.; Cervellati F.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/116739
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