Abstract PURPOSE: The relationship between neo-adjuvant chemotherapy prior to hepatectomy in patients with resectable colorectal liver metastases and post-operative morbidity still has to be clarified. METHODS: Data from 242 patients undergoing hepatectomy for colorectal liver metastases, judged resectable at first observation, were reviewed and their clinical outcome was related to neo-adjuvant chemotherapy (125 patients). Selection biases were outlined and properly handled by means of propensity score analysis. RESULTS: Post-operative death was 1.2% and morbidity 40.9%. Pre-operative chemotherapy was only apparently related to higher morbidity (P = 0.021): multivariate analysis identified extension of hepatectomy and intra-operative blood loss as independent prognostic variables (P 
Cucchetti A, Ercolani G, Cescon M, Di Gioia P, Peri E, Brandi G, et al. (2012). Safety of hepatic resection for colorectal metastases in the era of neo-adjuvant chemotherapy. LANGENBECK'S ARCHIVES OF SURGERY, 397(3), 397-405 [10.1007/s00423-011-0894-4].
Safety of hepatic resection for colorectal metastases in the era of neo-adjuvant chemotherapy.
CUCCHETTI, ALESSANDRO;ERCOLANI, GIORGIO;CESCON, MATTEO;BRANDI, GIOVANNI;PINNA, ANTONIO DANIELE
2012
Abstract
Abstract PURPOSE: The relationship between neo-adjuvant chemotherapy prior to hepatectomy in patients with resectable colorectal liver metastases and post-operative morbidity still has to be clarified. METHODS: Data from 242 patients undergoing hepatectomy for colorectal liver metastases, judged resectable at first observation, were reviewed and their clinical outcome was related to neo-adjuvant chemotherapy (125 patients). Selection biases were outlined and properly handled by means of propensity score analysis. RESULTS: Post-operative death was 1.2% and morbidity 40.9%. Pre-operative chemotherapy was only apparently related to higher morbidity (P = 0.021): multivariate analysis identified extension of hepatectomy and intra-operative blood loss as independent prognostic variables (PI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
