xThe synthesis of architecturally complex polycyclic fused indolines is achieved in a chemo-, regio-, and stereodefined manner, via an enantioselective gold-catalyzed cascade hydroindolination/iminium trapping synthetic sequence. Highly functionalized tetracyclic fused furoindolines (2) and dihydropyranylindolines (4) are synthesized in moderate to good yields and enantiomeric excesses of up to 87%.
G. Cera, M. Chiarucci, A. Mazzanti, M. Mancinelli, M. Bandini (2012). Enantioselective Gold-Catalyzed Synthesis of Polycyclic Indolines. ORGANIC LETTERS, 14(5), 1350-1353 [10.1021/ol300297t].
Enantioselective Gold-Catalyzed Synthesis of Polycyclic Indolines
CERA, GIANPIERO;CHIARUCCI, MICHEL;MAZZANTI, ANDREA;MANCINELLI, MICHELE;BANDINI, MARCO
2012
Abstract
xThe synthesis of architecturally complex polycyclic fused indolines is achieved in a chemo-, regio-, and stereodefined manner, via an enantioselective gold-catalyzed cascade hydroindolination/iminium trapping synthetic sequence. Highly functionalized tetracyclic fused furoindolines (2) and dihydropyranylindolines (4) are synthesized in moderate to good yields and enantiomeric excesses of up to 87%.File in questo prodotto:
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