Nonabortal pregnancy complications of chorionic villous sampling.

PURPOSE OF REVIEW: First trimester screening for genetic diseases has become the predominant tool for selecting higher risk women in developed countries. As a consequence, chorionic villous sampling (CVS) is considered the most effective method for early diagnosis. The purpose of this review is to report recent updates related to CVS complications. RECENT FINDINGS: The most recent data about CVS-related complications are more optimistic than in the past. These improved results are probably due to more advanced instruments used, more proper operator training and 30 years of medical experience of several centers. SUMMARY: Currently CVS is the gold standard method of first trimester prenatal diagnosis. Because it will likely be in higher demand in the next years, knowledge of the associated complications and their frequency is worth noting for both physicians and patients. Recent data have clarified some controversies and speculations but the magnitude of the association between CVS and fetal and obstetrical complications is still unclear. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.