Nowadays, efforts are dedicated to develop new biodegradable polymers for soft tissues engineering, where scaffolds displaying high elasticity are required in order to resist to long-term cyclic strains. These mechanical performances can be achieved by few synthetic biodegradabile polymers (e.g. Degrapol®, poly(glycerol sebacate) and poly(lactide-co-trimethylene carbonate)) whereas the most extensively used polyester (e.g. polycaprolactone, polylactide and poly(lactide-co-glycolide)) are too stiff to be suitable for engineering soft tissues. Therefore, nowadays, efforts are dedicated to develop new biodegradable elastomers. Reactive blending is a synthetic method that potentially enables to synthesize an infinite number of both block and random copolyesters by exploiting the transesterification reactions occurring at high temperatures. In this work new copolyesters of poly(butylene succinate), synthesized by reactive blending, are used to fabricate electrospun (ES) scaffolds displaying low elastic modulus. Biocompatibility of the new ES scaffolds is evaluated through embrionic rat cardiac cell culture.
M.L. Focarete, C. Gualandi, M Soccio, N. Lotti, M. Govoni, E. Giordano, et al. (2011). New biodegradable polyesters for soft tissue engineering. S.N. : s.n.
New biodegradable polyesters for soft tissue engineering
FOCARETE, MARIA LETIZIA;GUALANDI, CHIARA;SOCCIO, MICHELINA;LOTTI, NADIA;GOVONI, MARCO;GIORDANO, EMANUELE DOMENICO;VALENTE, SABRINA;PASQUINELLI, GIANANDREA
2011
Abstract
Nowadays, efforts are dedicated to develop new biodegradable polymers for soft tissues engineering, where scaffolds displaying high elasticity are required in order to resist to long-term cyclic strains. These mechanical performances can be achieved by few synthetic biodegradabile polymers (e.g. Degrapol®, poly(glycerol sebacate) and poly(lactide-co-trimethylene carbonate)) whereas the most extensively used polyester (e.g. polycaprolactone, polylactide and poly(lactide-co-glycolide)) are too stiff to be suitable for engineering soft tissues. Therefore, nowadays, efforts are dedicated to develop new biodegradable elastomers. Reactive blending is a synthetic method that potentially enables to synthesize an infinite number of both block and random copolyesters by exploiting the transesterification reactions occurring at high temperatures. In this work new copolyesters of poly(butylene succinate), synthesized by reactive blending, are used to fabricate electrospun (ES) scaffolds displaying low elastic modulus. Biocompatibility of the new ES scaffolds is evaluated through embrionic rat cardiac cell culture.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
