We developed a novel molecular magnetic resonance (MR) imaging method to monitor accumulation of macrophages at the infection site infection. Positive-contrast molecular MR imaging provides an alternative to negative-contrast molecular MRI imaging, exploiting the chemical shift induced by ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles to nearby water molecules. We introduced a novel combination of off-resonance (ORI) positive-contrast MRI and T2p relaxation in the rotating frame (ORI-T2()) for positive-contrast MR imaging of USPIO. We used this new method for testing a new anti-infective compound M50 following Pseudomonas aeruginosa infection..
Combined off-resonance imaging and relaxation in the rotating frame for positive contrast imaging of infection in a murine burn model testing a novel anti-infective compound / V. Righi; M. Starkey; J. He; G. Dai; V. Tugnoli; L.G. Rahme; R.G. Tompkins; A.A. Tzika. - STAMPA. - (2011), pp. 923-923. (Intervento presentato al convegno !9th annual ISMRM Scientific Meeting and Exhibition 2011 tenutosi a Montreal (Canada) nel May 7-13, 2011).
Combined off-resonance imaging and relaxation in the rotating frame for positive contrast imaging of infection in a murine burn model testing a novel anti-infective compound.
RIGHI, VALERIA;TUGNOLI, VITALIANO;
2011
Abstract
We developed a novel molecular magnetic resonance (MR) imaging method to monitor accumulation of macrophages at the infection site infection. Positive-contrast molecular MR imaging provides an alternative to negative-contrast molecular MRI imaging, exploiting the chemical shift induced by ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles to nearby water molecules. We introduced a novel combination of off-resonance (ORI) positive-contrast MRI and T2p relaxation in the rotating frame (ORI-T2()) for positive-contrast MR imaging of USPIO. We used this new method for testing a new anti-infective compound M50 following Pseudomonas aeruginosa infection..I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.