The 1-(2-nitrophenyl)-2-(2-methylphenyl)-1,4,5,6-tetrahydropyrimidine and its five- and seven-membered ring analogs were synthesized and their conformational properties investigated by low temperature NMR spectroscopy and DFT theoretical calculations. Restricted rotation of the aryl substituents were observed in all cases and the corresponding barriers determined. In the case of the sixmembered ring derivative the additional conformers resulting from a ring inversion process were also detected.
J. E. Dìaz, N. Gruber, L. Lunazzi, A. Mazzanti, L. R. Orelli (2011). Conformation and stereodynamics of 1,2-diaryltetrahydropyrimidine and of its five- and seven-membered ring analogs. TETRAHEDRON, 67, 9129-9133 [10.1016/j.tet.2011.09.091].
Conformation and stereodynamics of 1,2-diaryltetrahydropyrimidine and of its five- and seven-membered ring analogs
LUNAZZI, LODOVICO;MAZZANTI, ANDREA;
2011
Abstract
The 1-(2-nitrophenyl)-2-(2-methylphenyl)-1,4,5,6-tetrahydropyrimidine and its five- and seven-membered ring analogs were synthesized and their conformational properties investigated by low temperature NMR spectroscopy and DFT theoretical calculations. Restricted rotation of the aryl substituents were observed in all cases and the corresponding barriers determined. In the case of the sixmembered ring derivative the additional conformers resulting from a ring inversion process were also detected.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
