(3R,4S,1′S)-4-Amino-1-(1′-(4-methoxyphenyl)ethyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid (AMMOPC) gives a foldamer with an 8-helix conformation. When it was inserted in the 12-helix foldamer of (3R,4S,1′S)-4-amino-1-(1′-(4-methoxyphenyl)ethyl)-5-oxo-pyrrolidine-3-carboxylic acid (AMOPC), it locally induced formation of an 8-helix conformation
R. Galeazzi, G. Martelli, A. Mazzanti, M. Orena, S. Rinaldi (2011). Quaternary Centres as a Tool for Modulating Foldamer Conformation. CHEMISTRY-A EUROPEAN JOURNAL, 17, 12564-12568 [10.1002/chem.201102103].
Quaternary Centres as a Tool for Modulating Foldamer Conformation.
MAZZANTI, ANDREA;
2011
Abstract
(3R,4S,1′S)-4-Amino-1-(1′-(4-methoxyphenyl)ethyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid (AMMOPC) gives a foldamer with an 8-helix conformation. When it was inserted in the 12-helix foldamer of (3R,4S,1′S)-4-amino-1-(1′-(4-methoxyphenyl)ethyl)-5-oxo-pyrrolidine-3-carboxylic acid (AMOPC), it locally induced formation of an 8-helix conformationFile in questo prodotto:
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