An efficient synthesis of spiropyrazolones based in organocatalysis is described. The reaction between pyrazolones, enolizable aldehydes and enals is catalyzed by secondary amine 10 catalysts and affords the final spiro compounds bearing four contiguous chiral centers in good yields and excellent diastereo and enantioselectivities
A. Zea, A-N.R. Alba, A. Mazzanti, A. Moyano, R. Rios (2011). Highly enantioselective cascade synthesis of spiropyrazolones. ORGANIC & BIOMOLECULAR CHEMISTRY, 9, 6519-6523 [10.1039/c1ob05753g].
Highly enantioselective cascade synthesis of spiropyrazolones
MAZZANTI, ANDREA;
2011
Abstract
An efficient synthesis of spiropyrazolones based in organocatalysis is described. The reaction between pyrazolones, enolizable aldehydes and enals is catalyzed by secondary amine 10 catalysts and affords the final spiro compounds bearing four contiguous chiral centers in good yields and excellent diastereo and enantioselectivitiesFile in questo prodotto:
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