The purpose of this study was to analyse the chemical composition of Spartium junceum L. (also known as Spanish Broom) aromatic water and to evaluate its cytotoxic activity against a series of human cancer cell lines (melanoma: RPMI 7932; leukaemia: K562; breast cancer cell: MCF7-Bart and MCF7-ICLC, colon adenocarcinoma: SW480). The results show that aromatic water was cytotoxic toward the tumor cell lines analysed (RPMI 7932, K562, MCF7-Bart, MCF7-ICLC, SW480), while it did not appreciably alter the viability of the normal keratinocyte (NCTC 2544) suggesting its potential use as an antitumoral agent for cancer treatment and/or prevention.
T. Cerchiara, S.V. Straface, G. Chidichimo, E.L. Belsito, A. Liguori, B. Luppi, et al. (2012). Spartium junceum Aromatic Water: chemical composition and antitumor activity. NATURAL PRODUCT COMMUNICATIONS, 7, 137-140.
Spartium junceum Aromatic Water: chemical composition and antitumor activity
CERCHIARA, TERESA;LUPPI, BARBARA;BIGUCCI, FEDERICA;ZECCHI, VITTORIO
2012
Abstract
The purpose of this study was to analyse the chemical composition of Spartium junceum L. (also known as Spanish Broom) aromatic water and to evaluate its cytotoxic activity against a series of human cancer cell lines (melanoma: RPMI 7932; leukaemia: K562; breast cancer cell: MCF7-Bart and MCF7-ICLC, colon adenocarcinoma: SW480). The results show that aromatic water was cytotoxic toward the tumor cell lines analysed (RPMI 7932, K562, MCF7-Bart, MCF7-ICLC, SW480), while it did not appreciably alter the viability of the normal keratinocyte (NCTC 2544) suggesting its potential use as an antitumoral agent for cancer treatment and/or prevention.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
