This study takes the first step toward in situ analysis of powder drugs which does not require any alteration of the samples. A fast, inexpensive analytical method based on reflectance near-infrared spectrometry and multivariate calibration was applied. Samples were laboratory-prepared ternary powders (diacetylmorphine, caffeine, and paracetamol) chosen through a D-optimal experimental design. Partial least squares regression was applied.
Rapid In Situ Repeatable Analysis of Drugs in Powder Form Using Reflectance Near-Infrared Spectroscopy and Multivariate Calibration
MELUCCI, DORA;MONTI, DARIO;M. D'Elia;
2012
Abstract
This study takes the first step toward in situ analysis of powder drugs which does not require any alteration of the samples. A fast, inexpensive analytical method based on reflectance near-infrared spectrometry and multivariate calibration was applied. Samples were laboratory-prepared ternary powders (diacetylmorphine, caffeine, and paracetamol) chosen through a D-optimal experimental design. Partial least squares regression was applied.File in questo prodotto:
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