This study takes the first step toward in situ analysis of powder drugs which does not require any alteration of the samples. A fast, inexpensive analytical method based on reflectance near-infrared spectrometry and multivariate calibration was applied. Samples were laboratory-prepared ternary powders (diacetylmorphine, caffeine, and paracetamol) chosen through a D-optimal experimental design. Partial least squares regression was applied.
D. Melucci, D. Monti, M. D'Elia, G. Luciano (2012). Rapid In Situ Repeatable Analysis of Drugs in Powder Form Using Reflectance Near-Infrared Spectroscopy and Multivariate Calibration. JOURNAL OF FORENSIC SCIENCES, 57, 86-92 [10.1111/j.1556-4029.2011.01945.x].
Rapid In Situ Repeatable Analysis of Drugs in Powder Form Using Reflectance Near-Infrared Spectroscopy and Multivariate Calibration
MELUCCI, DORA;MONTI, DARIO;M. D'Elia;
2012
Abstract
This study takes the first step toward in situ analysis of powder drugs which does not require any alteration of the samples. A fast, inexpensive analytical method based on reflectance near-infrared spectrometry and multivariate calibration was applied. Samples were laboratory-prepared ternary powders (diacetylmorphine, caffeine, and paracetamol) chosen through a D-optimal experimental design. Partial least squares regression was applied.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
