The conformational and structural properties of the six-membered heterocyclic ring of 1-methyl-4-piperidone have been observed in a jet-cooled supersonic expansion using Fourier transform microwave spectroscopy (FT-MW). The rotational spectrum evidenced two different conformations originated by nitrogen inversion, with the N-methyl group in either equatorial (most stable) or axial position. Additional observation of the rotational spectra for all possible carbon, nitrogen, and oxygen monosubstituted species (4 13C, 15N, 18O) in natural abundance allowed us to determine substitution (rs) and effective structures (r0) for the equatorial conformer. Additional ab initio and DFT calculations provided comparative rotational parameters, structural data, conformational energies, and the axial equatorial interconversion barrier. The structural data were compared with the related azabicycle of tropinone, revealing the molecular changes and structural relaxation associated with the presence of the two-carbon bridge in the latter molecule.

L.Evangelisti, A.Lesarri, M.K.Jahn, E.J.Cocinero, W.Caminati, J.-U.Grabow (2011). N-Methyl Inversion and Structure of Six-Membered Heterocyclic Rings: Rotational Spectrum of 1-Methyl-4-piperidone. JOURNAL OF PHYSICAL CHEMISTRY. A, MOLECULES, SPECTROSCOPY, KINETICS, ENVIRONMENT, & GENERAL THEORY, 115, 9545-9551 [10.1021/jp112425w].

N-Methyl Inversion and Structure of Six-Membered Heterocyclic Rings: Rotational Spectrum of 1-Methyl-4-piperidone

EVANGELISTI, LUCA;CAMINATI, WALTHER;
2011

Abstract

The conformational and structural properties of the six-membered heterocyclic ring of 1-methyl-4-piperidone have been observed in a jet-cooled supersonic expansion using Fourier transform microwave spectroscopy (FT-MW). The rotational spectrum evidenced two different conformations originated by nitrogen inversion, with the N-methyl group in either equatorial (most stable) or axial position. Additional observation of the rotational spectra for all possible carbon, nitrogen, and oxygen monosubstituted species (4 13C, 15N, 18O) in natural abundance allowed us to determine substitution (rs) and effective structures (r0) for the equatorial conformer. Additional ab initio and DFT calculations provided comparative rotational parameters, structural data, conformational energies, and the axial equatorial interconversion barrier. The structural data were compared with the related azabicycle of tropinone, revealing the molecular changes and structural relaxation associated with the presence of the two-carbon bridge in the latter molecule.
2011
L.Evangelisti, A.Lesarri, M.K.Jahn, E.J.Cocinero, W.Caminati, J.-U.Grabow (2011). N-Methyl Inversion and Structure of Six-Membered Heterocyclic Rings: Rotational Spectrum of 1-Methyl-4-piperidone. JOURNAL OF PHYSICAL CHEMISTRY. A, MOLECULES, SPECTROSCOPY, KINETICS, ENVIRONMENT, & GENERAL THEORY, 115, 9545-9551 [10.1021/jp112425w].
L.Evangelisti; A.Lesarri; M.K.Jahn; E.J.Cocinero; W.Caminati; J.-U.Grabow
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/109209
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