1,3-Dipolar cycloadditions of C-carboxymethyl-N-aryl-nitrile imines with cyclic ,-unsaturated ketones of various size have been studied. After the cycloaddition, the oxidative aromatization gives the ring-fused pyrazoles. Computational studies and the use of the topological analysis of the Fukui functions allows a theoretical description of the local reactivity in agreement with the experimental observed high regiochemistry.
1,3-Dipolar Cycloaddition of Nitrile Imines with Cyclic alpha-beta-Unsaturated Ketones. A Highly Regiochemical Route to Ring-Fused Pyrazoles.
FEMONI, CRISTINA;FOCHI, MARIAFRANCESCA;COMES FRANCHINI, MAURO
2011
Abstract
1,3-Dipolar cycloadditions of C-carboxymethyl-N-aryl-nitrile imines with cyclic ,-unsaturated ketones of various size have been studied. After the cycloaddition, the oxidative aromatization gives the ring-fused pyrazoles. Computational studies and the use of the topological analysis of the Fukui functions allows a theoretical description of the local reactivity in agreement with the experimental observed high regiochemistry.File in questo prodotto:
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