The hepatic safety profile of ART including DRV/r was retrospectively evaluated in antiretroviral-experienced HIV-infected patients (18 HIV/HCV coinfected, group A and 29 infected with HIV alone, group B) during a 72 week study. During the study, liver enzyme values were higher in group A, but in the case of abnormal transaminase levels, the median values did not exceed 1.6xULN. This study showed evidence of long-lasting hepatic safety of ART including PI DRV/r in HIV/HCV coinfected and in HIV monoinfected persons.

Hepatic safety profile of darunavir with low dose ritonavir (DRV/r) in HIV/HCV coinfected and HIV monoinfected patients.

BIANCHI, GIAMPAOLO;
2011

Abstract

The hepatic safety profile of ART including DRV/r was retrospectively evaluated in antiretroviral-experienced HIV-infected patients (18 HIV/HCV coinfected, group A and 29 infected with HIV alone, group B) during a 72 week study. During the study, liver enzyme values were higher in group A, but in the case of abnormal transaminase levels, the median values did not exceed 1.6xULN. This study showed evidence of long-lasting hepatic safety of ART including PI DRV/r in HIV/HCV coinfected and in HIV monoinfected persons.
G. Morsica; G. Bianchi; S. Bagaglio; C. Conte; S. Salpietro; L. Porrino; C. Uberti-Foppa
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/108261
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