Stereoselective synthesis of non-proteinogenic di- and tri-peptides containing L-valine unit and a cyclic unnatural alpha-amino acid has been accomplished starting from the L-valine derived chiral synthon. The conformational preference of these unnatural peptides was investigated by 1H-NMR and IR spectroscopies and by molecular modelling calculations. X-ray analysis is also reported.
D. Balducci, E. Emer, F. Piccinelli, G. Porzi, M. Recanatini, S. Sandri (2005). Synthesis and conformational preferences of cyclic unnatural di- and tri-peptides containing L-Valine unit. Part 2. TETRAHEDRON-ASYMMETRY, 16, 3785-3794 [10.1016/j.tetasy.2005.10.030].
Synthesis and conformational preferences of cyclic unnatural di- and tri-peptides containing L-Valine unit. Part 2
BALDUCCI, DANIELE;EMER, ENRICO;PICCINELLI, FABIO;PORZI, GIANNI;RECANATINI, MAURIZIO;SANDRI, SERGIO
2005
Abstract
Stereoselective synthesis of non-proteinogenic di- and tri-peptides containing L-valine unit and a cyclic unnatural alpha-amino acid has been accomplished starting from the L-valine derived chiral synthon. The conformational preference of these unnatural peptides was investigated by 1H-NMR and IR spectroscopies and by molecular modelling calculations. X-ray analysis is also reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
