The first catalytic asymmetric Wittig reaction is presented. Hydrogen bond donors catalyze the [2 + 2] cycloaddition reaction between stablized phosphorous ylides and 4-substituted cyclohexanones, breaking their symmetry plane and furnishing axially chiral olefins with moderate stereoselectivities.
Organocatalytic asymmetric Wittig reactions: generation of enantioeneriched axially chiral olefins breaking a symmetry plane / L. Gramigna; S. Duce; G. Filippini; M. Fochi; M. Comes Franchini; L. Bernardi. - In: SYNLETT. - ISSN 0936-5214. - STAMPA. - 2011:(2011), pp. 2745-2749. [10.1055/s-0031-1289516]
Organocatalytic asymmetric Wittig reactions: generation of enantioeneriched axially chiral olefins breaking a symmetry plane
GRAMIGNA, LUCIA;FOCHI, MARIAFRANCESCA;COMES FRANCHINI, MAURO;BERNARDI, LUCA
2011
Abstract
The first catalytic asymmetric Wittig reaction is presented. Hydrogen bond donors catalyze the [2 + 2] cycloaddition reaction between stablized phosphorous ylides and 4-substituted cyclohexanones, breaking their symmetry plane and furnishing axially chiral olefins with moderate stereoselectivities.File in questo prodotto:
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