The first catalytic asymmetric Wittig reaction is presented. Hydrogen bond donors catalyze the [2 + 2] cycloaddition reaction between stablized phosphorous ylides and 4-substituted cyclohexanones, breaking their symmetry plane and furnishing axially chiral olefins with moderate stereoselectivities.
L. Gramigna, S. Duce, G. Filippini, M. Fochi, M. Comes Franchini, L. Bernardi (2011). Organocatalytic asymmetric Wittig reactions: generation of enantioeneriched axially chiral olefins breaking a symmetry plane. SYNLETT, 2011, 2745-2749 [10.1055/s-0031-1289516].
Organocatalytic asymmetric Wittig reactions: generation of enantioeneriched axially chiral olefins breaking a symmetry plane
GRAMIGNA, LUCIA;FOCHI, MARIAFRANCESCA;COMES FRANCHINI, MAURO;BERNARDI, LUCA
2011
Abstract
The first catalytic asymmetric Wittig reaction is presented. Hydrogen bond donors catalyze the [2 + 2] cycloaddition reaction between stablized phosphorous ylides and 4-substituted cyclohexanones, breaking their symmetry plane and furnishing axially chiral olefins with moderate stereoselectivities.File in questo prodotto:
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