The onset of a new infection by a pathogen requires a rapid and prompt response from the body. Here, we present a simple and effective strategy to stimulate antibody production by grafting immunogenic peptides onto a beta-strand peptide scaffold. Analysis of the method using a known immunogenic region, the disulfide loop of the PilA protein of the Pseudomonas aeruginosa pilus, shows that the molecule folds properly in solution and, upon vaccination of mice, provides significant protection against intravenous challenge with the P. aeruginosa PAK strain.
Trappetti, C., Van Ingen, H., Falconi, M., Romeo, A., Sancamillo, G., Caprini, M., et al. (2026). Structured peptides as vaccine antigens against infections. FRONTIERS IN IMMUNOLOGY, 17, 1908831-1908831 [10.3389/fimmu.2026.1908831].
Structured peptides as vaccine antigens against infections
Trappetti C.;Caprini M.;Oggioni M. R.;
2026
Abstract
The onset of a new infection by a pathogen requires a rapid and prompt response from the body. Here, we present a simple and effective strategy to stimulate antibody production by grafting immunogenic peptides onto a beta-strand peptide scaffold. Analysis of the method using a known immunogenic region, the disulfide loop of the PilA protein of the Pseudomonas aeruginosa pilus, shows that the molecule folds properly in solution and, upon vaccination of mice, provides significant protection against intravenous challenge with the P. aeruginosa PAK strain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
