There has been growing interest in investigating both the in vitro and in vivo detection of optical photons from a plethora of beta emitters using optical techniques. In this paper we have investigated an alpha particle induced fluorescence signal by using a commercial CCD-based small animal optical imaging system. The light emission of a 241Am source was simulated using GEANT4 and tested in different experimental conditions including the imaging of in vivo tissue.We believe that the results presented in this work can be useful to describe a possible mechanism for the in vivo detection of alpha emitters used for therapeutic purposes.
Boschi F., Lo Meo S., Rossi P.L., Calandrino R., Sbarbati A., Spinelli A.E. (2011). Optical imaging of alpha emitters: simulations, phantom, and in vivo results. JOURNAL OF BIOMEDICAL OPTICS, 16, 126011-1-126011-5 [10.1117/1.3663441].
Optical imaging of alpha emitters: simulations, phantom, and in vivo results.
Lo Meo S.;ROSSI, PIER LUCA;SPINELLI, ANTONELLO ENRICO
2011
Abstract
There has been growing interest in investigating both the in vitro and in vivo detection of optical photons from a plethora of beta emitters using optical techniques. In this paper we have investigated an alpha particle induced fluorescence signal by using a commercial CCD-based small animal optical imaging system. The light emission of a 241Am source was simulated using GEANT4 and tested in different experimental conditions including the imaging of in vivo tissue.We believe that the results presented in this work can be useful to describe a possible mechanism for the in vivo detection of alpha emitters used for therapeutic purposes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
