Relevance of Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal microenvironment

CANDELA, MARCO; TURRONI, SILVIA; CENTANNI, MANUELA; FIORI, JESSICA; Bergmann, S.; Hammerschmidt, S.; BRIGIDI, PATRIZIA

doi:10.1128/AEM.00413-11

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Human plasmin(ogen) is regarded as a component of the molecular cross talk between the probiotic species Bifidobacterium animalis subsp. lactis and the human host. However, up to now, only in vitro studies have been reported. Here, we demonstrate that the probiotic strain B. animalis subsp. lactis BI07 is capable of recruiting plasmin(ogen) present at physiological concentrations in crude extracts from human feces. Our results provide evidence that supports the significance of the B. lactis-plasmin(ogen) interaction in the human gastrointestinal tract.

Titolo:	Relevance of Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal microenvironment
Autore/i:	CANDELA, MARCO; TURRONI, SILVIA; CENTANNI, MANUELA; FIORI, JESSICA; Bergmann S.; Hammerschmidt S.; BRIGIDI, PATRIZIA
Autore/i Unibo:	CANDELA, MARCO TURRONI, SILVIA CENTANNI, MANUELA FIORI, JESSICA Bergmann S. Hammerschmidt S. BRIGIDI, PATRIZIA mostra contributor esterni nascondi contributor esterni
Anno:	2011
Rivista:	APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Digital Object Identifier (DOI):	http://dx.doi.org/10.1128/AEM.00413-11
Abstract:	Human plasmin(ogen) is regarded as a component of the molecular cross talk between the probiotic species Bifidobacterium animalis subsp. lactis and the human host. However, up to now, only in vitro studies have been reported. Here, we demonstrate that the probiotic strain B. animalis subsp. lactis BI07 is capable of recruiting plasmin(ogen) present at physiological concentrations in crude extracts from human feces. Our results provide evidence that supports the significance of the B. lactis-plasmin(ogen) interaction in the human gastrointestinal tract.
Data prodotto definitivo in UGOV:	2013-07-01 15:39:07
Data stato definitivo:	2020-02-27T17:25:36Z
Appare nelle tipologie:	1.01 Articolo in rivista

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