A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from diastereomeric monolactim ethers derived from L-valine. The compounds investigated were inactive towards beta-glucosidase, alpha-mannosidase and alpha-galactosidase, but behave as non-competitive inhibitors against the alpha-glucosidase (from Saccharomices Cervisiae) with some showing a good inhibition ability (0.05

A. Arcelli, D. Balducci, A. Grandi, G. Porzi, M. Sandri, S. Sandri (2005). Chiral 1,4-morpholin-2,5-dione derivatives as alpha-glucosidase inhibitors. Part 2. TETRAHEDRON-ASYMMETRY, 16, 1495-1501 [10.1016/j.tetasy.2005.03.007].

Chiral 1,4-morpholin-2,5-dione derivatives as alpha-glucosidase inhibitors. Part 2

ARCELLI, ANTONIO;BALDUCCI, DANIELE;PORZI, GIANNI;SANDRI, MONICA;SANDRI, SERGIO
2005

Abstract

A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from diastereomeric monolactim ethers derived from L-valine. The compounds investigated were inactive towards beta-glucosidase, alpha-mannosidase and alpha-galactosidase, but behave as non-competitive inhibitors against the alpha-glucosidase (from Saccharomices Cervisiae) with some showing a good inhibition ability (0.05
2005
A. Arcelli, D. Balducci, A. Grandi, G. Porzi, M. Sandri, S. Sandri (2005). Chiral 1,4-morpholin-2,5-dione derivatives as alpha-glucosidase inhibitors. Part 2. TETRAHEDRON-ASYMMETRY, 16, 1495-1501 [10.1016/j.tetasy.2005.03.007].
A. Arcelli; D. Balducci; A. Grandi; G. Porzi; M. Sandri; S. Sandri
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/10770
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