A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from diastereomeric monolactim ethers derived from L-valine. The compounds investigated were inactive towards beta-glucosidase, alpha-mannosidase and alpha-galactosidase, but behave as non-competitive inhibitors against the alpha-glucosidase (from Saccharomices Cervisiae) with some showing a good inhibition ability (0.05
Chiral 1,4-morpholin-2,5-dione derivatives as alpha-glucosidase inhibitors. Part 2 / A. Arcelli; D. Balducci; A. Grandi; G. Porzi; M. Sandri; S. Sandri. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 16:(2005), pp. 1495-1501. [10.1016/j.tetasy.2005.03.007]
Chiral 1,4-morpholin-2,5-dione derivatives as alpha-glucosidase inhibitors. Part 2
ARCELLI, ANTONIO;BALDUCCI, DANIELE;PORZI, GIANNI;SANDRI, MONICA;SANDRI, SERGIO
2005
Abstract
A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from diastereomeric monolactim ethers derived from L-valine. The compounds investigated were inactive towards beta-glucosidase, alpha-mannosidase and alpha-galactosidase, but behave as non-competitive inhibitors against the alpha-glucosidase (from Saccharomices Cervisiae) with some showing a good inhibition ability (0.05I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
