A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from diastereomeric monolactim ethers derived from L-valine. The compounds investigated were inactive towards beta-glucosidase, alpha-mannosidase and alpha-galactosidase, but behave as non-competitive inhibitors against the alpha-glucosidase (from Saccharomices Cervisiae) with some showing a good inhibition ability (0.05
A. Arcelli, D. Balducci, A. Grandi, G. Porzi, M. Sandri, S. Sandri (2005). Chiral 1,4-morpholin-2,5-dione derivatives as alpha-glucosidase inhibitors. Part 2. TETRAHEDRON-ASYMMETRY, 16, 1495-1501 [10.1016/j.tetasy.2005.03.007].
Chiral 1,4-morpholin-2,5-dione derivatives as alpha-glucosidase inhibitors. Part 2
ARCELLI, ANTONIO;BALDUCCI, DANIELE;PORZI, GIANNI;SANDRI, MONICA;SANDRI, SERGIO
2005
Abstract
A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from diastereomeric monolactim ethers derived from L-valine. The compounds investigated were inactive towards beta-glucosidase, alpha-mannosidase and alpha-galactosidase, but behave as non-competitive inhibitors against the alpha-glucosidase (from Saccharomices Cervisiae) with some showing a good inhibition ability (0.05File in questo prodotto:
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