The crystal structure of Helicobacter pylori holo-NikR, a Ni2+-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies.
S. Benini, M. Cianci, S. Ciurli (2011). Holo-Ni2+ Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH. DALTON TRANSACTIONS, 40, 7831-7833 [10.1039/c1dt11107h].
Holo-Ni2+ Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH
CIURLI, STEFANO LUCIANO
2011
Abstract
The crystal structure of Helicobacter pylori holo-NikR, a Ni2+-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies.File in questo prodotto:
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