Folates are water-soluble B-group vitamin that are cofactors in many metabolic pathways such as DNA synthesis and methylation pathways. Humans cannot synthesize folate and its low status has been implicated in a wide variety of disorders. Naturally occurring food folates occur in abundance in leafy green vegetables, yeast extracts, citrus fruit, liver and kidney. Folate could derived, other than from diet, from indigenous bacteria of the microbiota which posses the ability of de novo folate production. Intestinal bacteria such as bifidobacteria can produce this cofactor by themselves from simple precursors; howewer some bifidobacteria are auxotrophic and have a strict growth requirement for folic acid. The study of folate metabolism in bifidobacteria isolated from different animals, such as omnivorous, herbivorous and carnivorous, could advances the knowledge of host-interaction in relation to endogenous folate production for possible microbiota modulation. We aimed to investigate the production of folate by bifidobacteria isolated from animals differing in diet in order to assess the potential indigenous contribute of folate availability provided by the microbiota.We aimed to investigate the production of folate by bifidobacteria isolated from animals differing in diet in order to assess the potential indigenous contribute of folate availability provided by the microbiota.

Folate production in bifidobacteria from omnivores, herbivores and carnivores

MATTARELLI, PAOLA;BIAVATI, BRUNO;MODESTO, MONICA MARIANNA;SGORBATI, BARBARA
2011

Abstract

Folates are water-soluble B-group vitamin that are cofactors in many metabolic pathways such as DNA synthesis and methylation pathways. Humans cannot synthesize folate and its low status has been implicated in a wide variety of disorders. Naturally occurring food folates occur in abundance in leafy green vegetables, yeast extracts, citrus fruit, liver and kidney. Folate could derived, other than from diet, from indigenous bacteria of the microbiota which posses the ability of de novo folate production. Intestinal bacteria such as bifidobacteria can produce this cofactor by themselves from simple precursors; howewer some bifidobacteria are auxotrophic and have a strict growth requirement for folic acid. The study of folate metabolism in bifidobacteria isolated from different animals, such as omnivorous, herbivorous and carnivorous, could advances the knowledge of host-interaction in relation to endogenous folate production for possible microbiota modulation. We aimed to investigate the production of folate by bifidobacteria isolated from animals differing in diet in order to assess the potential indigenous contribute of folate availability provided by the microbiota.We aimed to investigate the production of folate by bifidobacteria isolated from animals differing in diet in order to assess the potential indigenous contribute of folate availability provided by the microbiota.
uegweek 19th United European Gastroenterology Week
A 175
A 175
GUT
D'Aimmo M. R.; Andlid T.; Mattarelli P.; Biavati B.; Modesto M.; Sgorbati B.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/106409
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact