A series of chiral 1,4-morpholine-2,5-dione derivatives were synthesized. These substrates behave as non competitive inhibitors against the alpha-glucosidase showing a moderate inhibition (Ki < 0.8 mM) and were found inactive towards beta-glucosidase.

Chiral 1,4-morpholin-2,5-dione derivatives : synthesis and evaluation as glucosidase inhibitors / A. Arcelli; D. Balducci; A. Grandi; G. Porzi; M. Sandri; S. Sandri. - In: MONATSHEFTE FÜR CHEMIE. - ISSN 0026-9247. - STAMPA. - 135:(2004), pp. 951-958. [10.1007/s00706-004-0195-5]

Chiral 1,4-morpholin-2,5-dione derivatives : synthesis and evaluation as glucosidase inhibitors

ARCELLI, ANTONIO;BALDUCCI, DANIELE;PORZI, GIANNI;SANDRI, MONICA;SANDRI, SERGIO
2004

Abstract

A series of chiral 1,4-morpholine-2,5-dione derivatives were synthesized. These substrates behave as non competitive inhibitors against the alpha-glucosidase showing a moderate inhibition (Ki < 0.8 mM) and were found inactive towards beta-glucosidase.
2004
Chiral 1,4-morpholin-2,5-dione derivatives : synthesis and evaluation as glucosidase inhibitors / A. Arcelli; D. Balducci; A. Grandi; G. Porzi; M. Sandri; S. Sandri. - In: MONATSHEFTE FÜR CHEMIE. - ISSN 0026-9247. - STAMPA. - 135:(2004), pp. 951-958. [10.1007/s00706-004-0195-5]
A. Arcelli; D. Balducci; A. Grandi; G. Porzi; M. Sandri; S. Sandri
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/10628
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