A series of chiral 1,4-morpholine-2,5-dione derivatives were synthesized. These substrates behave as non competitive inhibitors against the alpha-glucosidase showing a moderate inhibition (Ki < 0.8 mM) and were found inactive towards beta-glucosidase.
A. Arcelli, D. Balducci, A. Grandi, G. Porzi, M. Sandri, S. Sandri (2004). Chiral 1,4-morpholin-2,5-dione derivatives : synthesis and evaluation as glucosidase inhibitors. MONATSHEFTE FÜR CHEMIE, 135, 951-958 [10.1007/s00706-004-0195-5].
Chiral 1,4-morpholin-2,5-dione derivatives : synthesis and evaluation as glucosidase inhibitors
ARCELLI, ANTONIO;BALDUCCI, DANIELE;PORZI, GIANNI;SANDRI, MONICA;SANDRI, SERGIO
2004
Abstract
A series of chiral 1,4-morpholine-2,5-dione derivatives were synthesized. These substrates behave as non competitive inhibitors against the alpha-glucosidase showing a moderate inhibition (Ki < 0.8 mM) and were found inactive towards beta-glucosidase.File in questo prodotto:
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