Post-reperfusion syndrome (PRS) during isolated intestinal Background: transplantation (ITx) is characterized by decreased systemic blood pressure, systemic vascular resistance, and cardiac output and by a moderate increased pulmonary arterial pressure. We hypothesize that the more severe PRS causes a poorer long-term outcome. The primary aim of this study was to determine the independent clinical predictors of intra-operative PRS, as well as to investigate the link between the severity of PRS and the intra-operative profiles and to examine the post-operative complications and their relationship This observational study was conducted on 27 with transplant outcome. Methods: patients undergoing isolated ITx in a single adult liver and multivisceral transplantation center. PRS was considered when the mean arterial blood pressure min was 30% lower than the pre-unclamping value and lasted for at least one The main results of min after unclamping. Results and conclusions: within 10 this study can be summarized in two findings: in patients undergoing ITx, the duration of cold ischemia and the pre-operative glomerular filtration rate were independent predictors of PRS and the occurrence of intra-operative PRS was associated with significantly more frequent post-operative renal failure and early post-operative death.

Post-reperfusion syndrome during isolated intestinal transplantation: outcome and predictors

SINISCALCHI, ANTONIO;CUCCHETTI, ALESSANDRO;ZANONI, ANDREA;AURINI, LUCIA;PINNA, ANTONIO DANIELE;FAENZA, STEFANO
2012

Abstract

Post-reperfusion syndrome (PRS) during isolated intestinal Background: transplantation (ITx) is characterized by decreased systemic blood pressure, systemic vascular resistance, and cardiac output and by a moderate increased pulmonary arterial pressure. We hypothesize that the more severe PRS causes a poorer long-term outcome. The primary aim of this study was to determine the independent clinical predictors of intra-operative PRS, as well as to investigate the link between the severity of PRS and the intra-operative profiles and to examine the post-operative complications and their relationship This observational study was conducted on 27 with transplant outcome. Methods: patients undergoing isolated ITx in a single adult liver and multivisceral transplantation center. PRS was considered when the mean arterial blood pressure min was 30% lower than the pre-unclamping value and lasted for at least one The main results of min after unclamping. Results and conclusions: within 10 this study can be summarized in two findings: in patients undergoing ITx, the duration of cold ischemia and the pre-operative glomerular filtration rate were independent predictors of PRS and the occurrence of intra-operative PRS was associated with significantly more frequent post-operative renal failure and early post-operative death.
Siniscalchi A.; Cucchetti A.; Miklosova Z.; Lauro A.; Zanoni A.; Spedicato S.; Bernardi E.; Aurini L.; Pinna AD; Faenza S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/106266
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