BACKGROUND: Prevalence of mental disorders in chronic pain varies widely across studies and can be overestimated using screening tools. The main aims of this cross-sectional investigation were to estimate baseline prevalence of previous clinically assessed psychiatric comorbidity in a chronic pain population during their first contact within an Italian specialist pain clinic, and to examine differences in socio-demographic, clinical, and pain features between patients with and without this comorbidity. An additional aim was to explore prevalence of current psychopathology in the subgroup without psychiatric comorbidity. METHODS: One-hundred-seventy-two participants were enrolled within the “Pain Therapy Service” at the Parma University Hospital. They completed the Brief Pain Inventory (BPI) and the Millon Clinical Multiaxial Inventory-III edition (MCMI-III). Inter-group comparisons were analyzed using the χ2 or the Mann-Whitney U Test. RESULTS: Thirty-one (18%) participants had a previous clinically assessed psychiatric comorbidity, especially depressive disorder (9.9%). Comorbid patients were more likely to be unemployed and to have longer pain duration, higher BPI severity and interference scores, and fixed-dose analgesic treatment. They also had a greater prevalence of current major depression. Notably, 51.8% (N.=73) of individuals without psychiatric comorbidity showed MCMI-III scores indicative of the current presence of clinically relevant psychiatric syndromes, especially anxiety and somatoform disorders. CONCLUSIONS: Although psychiatric illnesses are more frequent among patients with chronic pain than in the general population, a large proportion of them remain undiagnosed and potentially undertreated. A stable presence of mental health professionals within multidisciplinary teams for chronic pain treatment is recommended.

Pelizza, L., Pupo, S., Barbi, C., Alessia Incardona, M., Musetti, G., Menchetti, M. (2026). What psychiatric comorbidity in chronic pain? New insights for an “old,” underestimated issue. MINERVA PSYCHIATRY, 67, 22-34 [10.23736/S2724-6612.26.02679-5].

What psychiatric comorbidity in chronic pain? New insights for an “old,” underestimated issue.

Lorenzo PELIZZA
Primo
;
Marco MENCHETTI
Ultimo
2026

Abstract

BACKGROUND: Prevalence of mental disorders in chronic pain varies widely across studies and can be overestimated using screening tools. The main aims of this cross-sectional investigation were to estimate baseline prevalence of previous clinically assessed psychiatric comorbidity in a chronic pain population during their first contact within an Italian specialist pain clinic, and to examine differences in socio-demographic, clinical, and pain features between patients with and without this comorbidity. An additional aim was to explore prevalence of current psychopathology in the subgroup without psychiatric comorbidity. METHODS: One-hundred-seventy-two participants were enrolled within the “Pain Therapy Service” at the Parma University Hospital. They completed the Brief Pain Inventory (BPI) and the Millon Clinical Multiaxial Inventory-III edition (MCMI-III). Inter-group comparisons were analyzed using the χ2 or the Mann-Whitney U Test. RESULTS: Thirty-one (18%) participants had a previous clinically assessed psychiatric comorbidity, especially depressive disorder (9.9%). Comorbid patients were more likely to be unemployed and to have longer pain duration, higher BPI severity and interference scores, and fixed-dose analgesic treatment. They also had a greater prevalence of current major depression. Notably, 51.8% (N.=73) of individuals without psychiatric comorbidity showed MCMI-III scores indicative of the current presence of clinically relevant psychiatric syndromes, especially anxiety and somatoform disorders. CONCLUSIONS: Although psychiatric illnesses are more frequent among patients with chronic pain than in the general population, a large proportion of them remain undiagnosed and potentially undertreated. A stable presence of mental health professionals within multidisciplinary teams for chronic pain treatment is recommended.
2026
Pelizza, L., Pupo, S., Barbi, C., Alessia Incardona, M., Musetti, G., Menchetti, M. (2026). What psychiatric comorbidity in chronic pain? New insights for an “old,” underestimated issue. MINERVA PSYCHIATRY, 67, 22-34 [10.23736/S2724-6612.26.02679-5].
Pelizza, Lorenzo; Pupo, Simona; Barbi, Camilla; Alessia Incardona, Marika; Musetti, Giovanni; Menchetti, Marco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/1061896
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