The highly toxic oxyanion tellurite (TeO32-) enters the cells of the facultative photosynthetic bacterium Rhodobacter capsulatus through an acetate permease (ActP). Here we show that actP gene expression is down-regulated by fructose, and this in turn determines a strong decrease of tellurite uptake and a parallel increase in the cells resistance to the toxic metalloid (from a minimal inhibitory concentration of 8 mM up to 400 mM tellurite under aerobic growth conditions). This demonstrates that there exists a direct connection between the level of tellurite uptake and the sensitivity of the cells to the oxyanion.

Fructose increases the resistance of Rhodobacter capsulatus to the toxic oxyanion tellurite through repression of acetate permease (ActP).

BORGHESE, ROBERTO;ZANNONI, DAVIDE
2011

Abstract

The highly toxic oxyanion tellurite (TeO32-) enters the cells of the facultative photosynthetic bacterium Rhodobacter capsulatus through an acetate permease (ActP). Here we show that actP gene expression is down-regulated by fructose, and this in turn determines a strong decrease of tellurite uptake and a parallel increase in the cells resistance to the toxic metalloid (from a minimal inhibitory concentration of 8 mM up to 400 mM tellurite under aerobic growth conditions). This demonstrates that there exists a direct connection between the level of tellurite uptake and the sensitivity of the cells to the oxyanion.
R. Borghese; S. Cicerano; D. Zannoni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/106159
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