We report a series of endo-functionalized molecular receptors based on a calix[4]pyrrole scaffold, which exhibit Hydrogen Atom Transfer (HAT) reactivity towards free-radicals (e.g., peroxyl radicals). The chemical structure and shape of the molecular receptors affect the affinity towards free-radicals, while host-guest interactions are used to fine-tune the HAT reactivity, mimicking enzyme modulation in biological systems.
Pan, W., Grigoryeva, A., Bacchiocchi, C., Ballester, P., Valgimigli, L., Petroselli, M. (2025). Enzyme-like Hydrogen Atom Transfer (HAT) Based Endo-Functionalized Molecular Receptors. ORGANIC LETTERS, 27(51), 14201-14206 [10.1021/acs.orglett.5c04339].
Enzyme-like Hydrogen Atom Transfer (HAT) Based Endo-Functionalized Molecular Receptors
Pan, Wenkai;Grigoryeva, Anastasia;Bacchiocchi, Corrado;Valgimigli, Luca
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2025
Abstract
We report a series of endo-functionalized molecular receptors based on a calix[4]pyrrole scaffold, which exhibit Hydrogen Atom Transfer (HAT) reactivity towards free-radicals (e.g., peroxyl radicals). The chemical structure and shape of the molecular receptors affect the affinity towards free-radicals, while host-guest interactions are used to fine-tune the HAT reactivity, mimicking enzyme modulation in biological systems.| File | Dimensione | Formato | |
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OL 2025 ol5c04339_si_005.pdf
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OL 2025 ol5c04339_pre-editorial.pdf
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