PREZODE: a global co-designed collaboration for preventing zoonotic emergence

Despite decades of warnings, global health strategies still focus on detecting and responding to outbreaks rather than preventing zoonotic spillover in the first place. Upstream interventions that target environmental degradation, high-risk interfaces and socio-economic drivers of emergence are cost-effective and achievable but remain underfunded and politically sidelined. The PREZODE (preventing zoonotic disease emergence) global One Health initiative has developed a strategic agenda through a large-scale co-construction process involving scientists, communities, governments and practitioners. This agenda provides a roadmap for operationalizing upstream prevention.