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EnglishIn this study, vibrational Raman and IR spectroscopy coupled to thermogravimetry (TG) and differential scanning calorimetry (DSC) have been used to characterize the Proclear™ lens, a biomimetic soft contact lens composed of Omafilcon A, a phosphorylcholine (PC)-modified poly(2-hydroxyethyl-methacrylate) (PHEMA), whose main monomer is 2-methacryloyloxy-ethylphosphorylcholine. Raman and IR spectra showed that the PC component is actually incorporated into the polymer. The νOH Raman stretching region demonstrated that the Proclear™ lens contains a higher amount of water (59% by TG analysis) than commercial PHEMA lenses, confirming that the PC incorporation has noticeably altered the material properties. DSC comparative analysis was carried out on Proclear™ and PHEMA lenses as well as Acuvue™ (Etafilcon A), a commonly used soft contact lens with a water content comparable to that of Proclear™. The latter revealed to be characterized by a significantly higher free water fraction than PHEMA; this result explains why the former lens absorbs few tear components than the latter. Conversely, free water fraction was found to be nearly the same for Proclear™ and Acuvue™ lenses; the noticeably lower protein adsorption reported for the former was explained, partially at least, in relation to the different organization of water molecules in the two lenses.
| Titolo: | Raman, IR and thermal study of a new highly biocompatible phosphorylcholine-based contact lens |
| Autore/i: | TADDEI, PAOLA; F. Balducci; SIMONI, ROSA; MONTI, PATRIZIA |
| Autore/i Unibo: | |
| Anno: | 2005 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.molstruc.2004.10.118 |
| Abstract: | In this study, vibrational Raman and IR spectroscopy coupled to thermogravimetry (TG) and differential scanning calorimetry (DSC) have been used to characterize the Proclear™ lens, a biomimetic soft contact lens composed of Omafilcon A, a phosphorylcholine (PC)-modified poly(2-hydroxyethyl-methacrylate) (PHEMA), whose main monomer is 2-methacryloyloxy-ethylphosphorylcholine. Raman and IR spectra showed that the PC component is actually incorporated into the polymer. The νOH Raman stretching region demonstrated that the Proclear™ lens contains a higher amount of water (59% by TG analysis) than commercial PHEMA lenses, confirming that the PC incorporation has noticeably altered the material properties. DSC comparative analysis was carried out on Proclear™ and PHEMA lenses as well as Acuvue™ (Etafilcon A), a commonly used soft contact lens with a water content comparable to that of Proclear™. The latter revealed to be characterized by a significantly higher free water fraction than PHEMA; this result explains why the former lens absorbs few tear components than the latter. Conversely, free water fraction was found to be nearly the same for Proclear™ and Acuvue™ lenses; the noticeably lower protein adsorption reported for the former was explained, partially at least, in relation to the different organization of water molecules in the two lenses. |
| Data prodotto definitivo in UGOV: | 2005-10-06 15:11:55 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/11585/10580
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