Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease.
Immunoproteasome expression is induced in mesial temporal lobe epilepsy / Mishto M.; Ligorio C.; Bellavista E.; Martucci M.; Santoro A.; Giulioni M.; Marucci G.; Franceschi C.. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 408:(2011), pp. 65-70. [10.1016/j.bbrc.2011.03.117]
Immunoproteasome expression is induced in mesial temporal lobe epilepsy.
MISHTO, MICHELE;LIGORIO, CLAUDIA;BELLAVISTA, ELENA;MARTUCCI, MORENA;SANTORO, AURELIA;GIULIONI, MARCO;MARUCCI, GIANLUCA;FRANCESCHI, CLAUDIO
2011
Abstract
Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.