Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease.
Mishto M., Ligorio C., Bellavista E., Martucci M., Santoro A., Giulioni M., et al. (2011). Immunoproteasome expression is induced in mesial temporal lobe epilepsy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 408, 65-70 [10.1016/j.bbrc.2011.03.117].
Immunoproteasome expression is induced in mesial temporal lobe epilepsy.
MISHTO, MICHELE;LIGORIO, CLAUDIA;BELLAVISTA, ELENA;MARTUCCI, MORENA;SANTORO, AURELIA;GIULIONI, MARCO;MARUCCI, GIANLUCA;FRANCESCHI, CLAUDIO
2011
Abstract
Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
