Infections are an important cause of morbidity and mortality in patients with hematological malignancies, with the risk of infection being related to the severity and duration of drug-induced neutropenia. However, bloodstream infections are detected in only 30% to 40% of febrile neutropenic patients, suggesting that genetic host factors can increase susceptibility to infections and worsen outcomes. Here, we describe a patient with acute myeloid leukemia who had unusual recurrence of severe Escherichia coli infections during drug-induced neutropenia and exhibited mutations in genes encoding for receptors of innate immunity, that is, Toll-like receptors (TLRs)
G. Rossini, M. Stanzani, M. Baccarani, G. Tolomelli, M.P. Landini, V. Sambri, et al. (2011). Systemic infections caused by Escherichia coli in a neutropenic patient with multiple TLR gene polymorphisms abolished by stem-cell transplantation. TRANSPLANTATION, 91, e49-e51 [10.1097/TP.0b013e31820cfdad].
Systemic infections caused by Escherichia coli in a neutropenic patient with multiple TLR gene polymorphisms abolished by stem-cell transplantation.
ROSSINI, GIADA;BACCARANI, MICHELE;LANDINI, MARIA PAOLA;SAMBRI, VITTORIO;VARANI, STEFANIA
2011
Abstract
Infections are an important cause of morbidity and mortality in patients with hematological malignancies, with the risk of infection being related to the severity and duration of drug-induced neutropenia. However, bloodstream infections are detected in only 30% to 40% of febrile neutropenic patients, suggesting that genetic host factors can increase susceptibility to infections and worsen outcomes. Here, we describe a patient with acute myeloid leukemia who had unusual recurrence of severe Escherichia coli infections during drug-induced neutropenia and exhibited mutations in genes encoding for receptors of innate immunity, that is, Toll-like receptors (TLRs)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
