RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas. However, it is not known yet whether it is an early or late event in the process of thyroid carcinogenesis. Here we demonstrate, by using a combined immunohistochemical and reverse-transcriptase-polymerase chain reaction based approach, that RET/PTC activation is present in 11 out of 26 occult thyroid papillary carcinomas analysed. Therefore, we conclude that it represents an early event in the process of thyroid cell transformation.

Viglietto, G., Chiappetta, G., Martinez-Tello, F.J., Fukunaga, F.H., Tallini, G., Rigopoulou, D., et al. (1995). RET/PTC oncogene activation is an early event in thyroid carcinogenesis. ONCOGENE, 11(6), 1207-1210.

RET/PTC oncogene activation is an early event in thyroid carcinogenesis

Tallini G.;
1995

Abstract

RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas. However, it is not known yet whether it is an early or late event in the process of thyroid carcinogenesis. Here we demonstrate, by using a combined immunohistochemical and reverse-transcriptase-polymerase chain reaction based approach, that RET/PTC activation is present in 11 out of 26 occult thyroid papillary carcinomas analysed. Therefore, we conclude that it represents an early event in the process of thyroid cell transformation.
1995
Viglietto, G., Chiappetta, G., Martinez-Tello, F.J., Fukunaga, F.H., Tallini, G., Rigopoulou, D., et al. (1995). RET/PTC oncogene activation is an early event in thyroid carcinogenesis. ONCOGENE, 11(6), 1207-1210.
Viglietto, G.; Chiappetta, G.; Martinez-Tello, F. J.; Fukunaga, F. H.; Tallini, G.; Rigopoulou, D.; Visconti, R.; Mastro, A.; Santoro, M.; Fusco, A....espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/1050747
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