Adipose tissue secretes biologically active mediators is adipokines. We: evaluate the effect of pioglitazone and acarbose oil adipokines and vascular remodelling markers during in oral glucose tolerance test (OGTT). Height and body weight, BMI, glycemic: and lipid profile, blood pressure, Nitrites/nitrates, ADR resistin. MMP-2. and MMP-9 were evaluated at titration beginning. after 3, 6 months, and at the study end in 473 type 2 diabetic patients. BMI and weight increased after full treatment with pioglitazone respect to acarbose. HbA(1c) decreased after titration period with pioglitazone compared to baseline and to acarbose. and after full treatment with pioglitazone compared to the end of titration period and to acarbose FPG decreased after full treatment with pioglitazone compared to the end of titration period. PPG decreased with acarbose after titration period respect to baseline and after full treatment respect to the end of titration period FPI and Homa index decreased after titration period with pioglitazone compared to baseline and to acarbose. and after full treatment with pioglitazone respect to the end of titration period and to acarbose ADP increased after titration period with pioglitazone compared to baseline and to acarbose, and after full treatment with pioglitazone compared to the end of titration period and to acarbose Resistin decreased after titration period with pioglitazone compared to baseline and to acarbose. and after full treatment with pioglitazone respect to acarbose Pioglitazone improves glucose metabolism and insulin-resistance compared to acarbose in type 2 diabetic patients already treated with metformin and sulphomlureas.

Modulation of adipokines and vascular remodelling markers during OGTT with acarbose or pioglitazone treatment.

CICERO, ARRIGO FRANCESCO GIUSEPPE
2009

Abstract

Adipose tissue secretes biologically active mediators is adipokines. We: evaluate the effect of pioglitazone and acarbose oil adipokines and vascular remodelling markers during in oral glucose tolerance test (OGTT). Height and body weight, BMI, glycemic: and lipid profile, blood pressure, Nitrites/nitrates, ADR resistin. MMP-2. and MMP-9 were evaluated at titration beginning. after 3, 6 months, and at the study end in 473 type 2 diabetic patients. BMI and weight increased after full treatment with pioglitazone respect to acarbose. HbA(1c) decreased after titration period with pioglitazone compared to baseline and to acarbose. and after full treatment with pioglitazone compared to the end of titration period and to acarbose FPG decreased after full treatment with pioglitazone compared to the end of titration period. PPG decreased with acarbose after titration period respect to baseline and after full treatment respect to the end of titration period FPI and Homa index decreased after titration period with pioglitazone compared to baseline and to acarbose. and after full treatment with pioglitazone respect to the end of titration period and to acarbose ADP increased after titration period with pioglitazone compared to baseline and to acarbose, and after full treatment with pioglitazone compared to the end of titration period and to acarbose Resistin decreased after titration period with pioglitazone compared to baseline and to acarbose. and after full treatment with pioglitazone respect to acarbose Pioglitazone improves glucose metabolism and insulin-resistance compared to acarbose in type 2 diabetic patients already treated with metformin and sulphomlureas.
G. Derosa; A. D'Angelo; S.A. Salvadeo; I. Ferrari; E. Fogari; A. Gravina; R. Mereu; I. Palumbo; P. Maffioli; S. Randazzo; A. Cicero
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/104866
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 14
social impact