: The presence of inositol lipids in the nucleus has been shown in the late 1980s and since then a considerable amount of interest has been raised about the role of these molecules in an autonomous nuclear signalling system different from that at both the plasma membrane and the cytoplasm. Here we review the main issues of nuclear structure and of nuclear inositol lipids and their related enzymes in cellular signaling, taking into account also the possible role in some human pathologies.
De Stefano, A., Mccubrey, J.A., Suh, P.G., Ramazzotti, G., Fiume, R., Ratti, S., et al. (2026). Inositide-dependent signal transduction in the nucleus: a virtuous path from the laboratory to the clinic. ADVANCES IN BIOLOGICAL REGULATION, 99, 1-9 [10.1016/j.jbior.2025.101142].
Inositide-dependent signal transduction in the nucleus: a virtuous path from the laboratory to the clinic
De Stefano A.;Suh P. G.;Ramazzotti G.;Fiume R.;Ratti S.;Follo M. Y.;Manzoli L.;Cocco L.
2026
Abstract
: The presence of inositol lipids in the nucleus has been shown in the late 1980s and since then a considerable amount of interest has been raised about the role of these molecules in an autonomous nuclear signalling system different from that at both the plasma membrane and the cytoplasm. Here we review the main issues of nuclear structure and of nuclear inositol lipids and their related enzymes in cellular signaling, taking into account also the possible role in some human pathologies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
