Ultrathin films (also called nanofilms) are two-dimensional (2-D) polymeric structures with potential application in biology, biotechnology, cosmetics and tissue engineering. Since they can be handled in liquid form with micropipettes or tweezers they have been proposed as flexible systems for cell adhesion and proliferation. In particular, with the aim of designing a novel patch for bone or tendon repair and healing, in this work the biocompatibility, adhesion and proliferation activity of Saos-2, MRC-5 and human and rat mesenchymal stem cells on poly(lactic acid) nanofilms were evaluated. The nanofilms did not impair the growth and differentiation of osteoblasts and chondrocytes. Moreover, nanofilm adhesion to rabbit joints was evident under ex vivo conditions

Pensabene V., Taccola S., Ricotti L., Ciofani G., Menciassi A., Perut F., et al. (2011). Flexible polymeric ultrathin film for mesenchymal stem cells differentiation. ACTA BIOMATERIALIA, 7, 2883-2891 [10.1016/j.actbio.2011.03.013].

Flexible polymeric ultrathin film for mesenchymal stem cells differentiation

SALERNO, MANUELA;BALDINI, NICOLA
2011

Abstract

Ultrathin films (also called nanofilms) are two-dimensional (2-D) polymeric structures with potential application in biology, biotechnology, cosmetics and tissue engineering. Since they can be handled in liquid form with micropipettes or tweezers they have been proposed as flexible systems for cell adhesion and proliferation. In particular, with the aim of designing a novel patch for bone or tendon repair and healing, in this work the biocompatibility, adhesion and proliferation activity of Saos-2, MRC-5 and human and rat mesenchymal stem cells on poly(lactic acid) nanofilms were evaluated. The nanofilms did not impair the growth and differentiation of osteoblasts and chondrocytes. Moreover, nanofilm adhesion to rabbit joints was evident under ex vivo conditions
2011
Pensabene V., Taccola S., Ricotti L., Ciofani G., Menciassi A., Perut F., et al. (2011). Flexible polymeric ultrathin film for mesenchymal stem cells differentiation. ACTA BIOMATERIALIA, 7, 2883-2891 [10.1016/j.actbio.2011.03.013].
Pensabene V.; Taccola S.; Ricotti L.; Ciofani G.; Menciassi A.; Perut F.; Salerno M.; Dario P.; Baldini N.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/104426
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